DAVIS JOSEPH UNCOVERS A NEW MECHANISM BEHIND NEURODEGENERATION

FLOGEN Star Outreach proudly highlights the latest breakthrough by Davis Joseph, Director of Biochemistry at FLOGEN Technologies Inc., Canada, whose new single-author study presents critical insights into the onset of neurodegenerative diseases such as Alzheimer’s and Parkinson's.

Published in the International Journal of Molecular Sciences, this open-access paper uncovers why 4E-BP2 protein deamidation occurs exclusively in axons — a question that puzzled scientists for years. 4E-BP2 is a vital brain protein, and its absence is linked to memory impairment and the progression of devastating brain disorders.

Read the full article: IJMS - Open Access

Joseph discovered that the axon's "proteasome-poor" environment — lacking in the machinery needed to clear damaged proteins — plays a fundamental role in this protein’s transformation. This finding sheds new light on how oxidative stress triggers damaging protein changes in the nervous system, paving the way for new therapeutic approaches.

"This experimentally validated discovery… is of seminal importance because it explains what causes a post-translational modification in the brain of all mammalian species, which has been conserved for over 90 million years." - Davis Joseph

The study offers another critical piece in the puzzle of neurodegenerative disease, bringing us closer to a cure for conditions affecting millions worldwide.

Following the success of his previous record-breaking article — which surpassed 10,000 downloads in 7 months — this research further establishes Joseph as a trailblazer in neuroscience and molecular medicine.

Joseph will present his findings in a plenary lecture at SIPS 2025, held from November 17–20 at the Dusit Thani Mactan Resort, Cebu, Philippines.

Watch the video:

Uncovering New Mechanisms to Cure Neurodegenerative Disease